Current perspectives on intrathecal drug delivery

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Current perspectives on intrathecal drug delivery

Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with oral or parenteral drug delivery. Recent expert panel consensus guidelines have provided care paths in the treatment of noc...

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Colon specific drug delivery has gained increased importance not just for the delivery of drugs for the treatment of local diseases associated with the colon but also as potential site for the systemic delivery of therapeutic peptide and proteins. To achieve successful colon targeted drug delivery, a drug needs to be protected from degradation, release and/or absorption in the upper portion of ...

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Colon Targeted Drug Delivery: Current and Novel Perspectives

In general, we know that small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to some other sites for absorption due to various factors like any disease condition, degradation related situations, for sustained release of drugs etc. Colon targeted drug delivery is a relatively new concept for the absorption of drugs as it offers near neutral pH. ...

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Fluid Mechanics of Intrathecal Drug Delivery

The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a larger dose continuously injected over a longer period. The subarachnoid space is modeled as an annular gap of constant or slowly varying cr...

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Perspectives on transdermal ultrasound mediated drug delivery

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ژورنال

عنوان ژورنال: Journal of Pain Research

سال: 2014

ISSN: 1178-7090

DOI: 10.2147/jpr.s37591